Open Access

Erratum to: A novel octavalent combined Erysipelas, Parvo and Leptospira vaccine provides (cross) protection against infection following challenge of pigs with 9 different Leptospira interrogans serovars

Porcine Health Management20151:20

DOI: 10.1186/s40813-015-0014-x

Published: 22 December 2015

The original article was published in Porcine Health Management 2015 1:16

Erratum

The tables and their references published in the original version of this article [1] were regretfully incorrectly typeset. The correct tables and table citations have been updated in the original article. The correct tables have also been published in this Erratum for quick reference.
Table 1

Average MAT titres after vaccination and challenge. Pigs were vaccinated twice (4-week interval) and challenged with different Leptospira serovar (sv) and serogroup (sg) challenge strains, 6 weeks after first vaccination. MAT titres homologous to challenge strain

   

avg MAT titres ± SD (log2), weeks after first vaccination

n

Group

Challenge with

0

4

6

10

9

vaccine

sv Canicola

<2

<2

9.6 ± 2.0

9.6 ± 1.3

10

control

sg Canicola

<2

<2

<2

10.3 ± 1.1

10

vaccine

sv Copenhageni

<2

<2

3.8 ± 1.2

9.6 ± 1.0

10

control

sg lcterohaemorrhagiae

<2

<2

<2

10.3 ± 0.7

10

vaccine

sv lcterohaemorrhagiae

<2

<2

<2

91 ± 3.3

10

control

sg lcterohaemorrhagiae

<2

<2

<2

8.7 ± 1.4

10

vaccine

sv Bananal / Liangguan

<2

<2

6.9 ± 1.4

9.3 ± 0.8

9

control

sg Grippotyphosa

<2

<2

<2

91 ± 0.8

8

vaccine

sv Grippotyphosa

<2

<2

4.6 ± 2.4

7.6 ± 1.3

10

control

sg Grippotyphosa

<2

<2

<2

2.0 ± 1.8

10

vaccine

sv Bratislava

<2

6.9 ± 1.2

10.4 ± 0.8

10.5 ± 1.1

9

control

sg Australis

<2

<2

<2

9.9 ± 1.2

9

vaccine

sv Pomona

<2

<2

5.0 ± 4.0

6.7 ± 3.2

10

control

sg Pomona

<2

<2

<2

9.6 ± 0.8

10

vaccine

sv Vughia

<2

<2

<2

8.5 ± 0.8

10

control

sg Tarassovi

<2

<2

<2

9.5 ± 1.0

10

vaccine

sv Tarassovi

<2

<2

2.0 ± 3.2

8.0 ± 1.3

10

control

sg Tarassovi

<2

<2

<2

4.3 ± 1.3

Table 2

Reisolation of Leptospira from blood. Pigs were vaccinated twice (4-week interval) and challenged with different Leptospira serovar (sv) and serogroup (sg) challenge strains, 6 weeks after first vaccination. A pig was considered infected if at least once a positive blood isolation was found. n.a. = not applicable

   

Reisolation of Leptospira from blood on post-challenge day

# pigs infected

# blood isolations

n

Group

Challenge with

0

1

2

3

4

7

10

9

vaccine

sv Canicola

0

0

0

0

0

0

0

0**

n. a.

10

control

sg Canicola

0

10

10

10

10

1

0

10

n. a.

10

vaccine

sv Copenhageni

0

0

0

0

0

0

0

0**

n. a.

10

control

sg lcterohaemorrhagiae

0

10

10

8

4

1

0

10

n. a.

10

vaccine

sv lcterohaemorrhagiae

0

2

0

0

0

0

0

2**

2**

10

control

sg lcterohaemorrhagiae

0

9

6

2

0

0

0

9

17

10

vaccine

sv Bananal / Liangguan

0

0

0

0

0

0

0

0**

n. a.

9

control

sg Grippotyphosa

0

6

8

6

2

0

0

8

n. a.

8

vaccine

sv Grippotyphosa

0

0

0

0

0

0

0

0**

n. a.

10

control

sg Grippotyphosa

0

6

1

0

0

0

0

6

n. a.

10

vaccine

sv Bratislava

0

0

0

0

0

0

0

0**

n. a.

9

control

sg Austrais

0

6

4

0

0

0

0

6

n. a.

9

vaccine

sv Pomona

0

0

0

0

0

0

0

0**

n. a.

10

control

sg Pomona

0

10

10

10

9

2

0

10

n. a.

10

vaccine

sv vughia

0

0

0

0

0

0

0

0**

n. a.

10

control

sg Tarassovi

0

10

9

1

1

0

0

10

n. a.

10

vaccine

sv Tarassovi

0

2

0

0

0

0

0

2

2*

10

control

sg Tarassovi

0

6

2

1

1

0

0

6

10

* p < 0.05. **p < 0.01

Table 3

Reisolation of Leptospira from urine and kidney. Pigs were vaccinated twice (4-week interval) and challenged with different Leptospira serovar (sv) and serogroup (sg) challenge strains, 6 weeks after first vaccination. Urine was sampled regularly and kidney samples were collected during necropsy 4w after challenge. A pig was considered shedding if at least once a positive urine isolation was found

   

Reisolation of Leptospira from urine on post-challenge day

# pigs shedding

# kidney positive

n

Group

Challenge with

0

14

17

21

24

28

9

vaccine

sv Canicola

0

0

0

0

0

0

0**

0**

10

control

sg Canicola

0

9

9

9

7

6

10

6

10

vaccine

sv Copenhageni

0

0

0

0

0

0

0

0

10

control

sg lcterohaemorrhagiae

0

0

0

0

1

1

1

0

**p < 0.01

Table 4

Leptospira strains used for vaccine / challenge

Species

Serogroup

Serovar

Strain

Originally isolated from

Leptospira interrogans

Canicola

Portland-verea

Ca-I 2-000

human blood, 1964, Jamaica

Leptospira interrogans

 

Canicolab

Moulton

pig urine, 2004, Netherlands

Leptospira interrogans

lcterohaemorrhagiae

Copenhagenia

lc-02-001

rat, kidney, 1978, USA

Leptospira interrogans

 

Copenhagenib

CF1

dog, 1969, Puerto Rico

Leptospira interrogans

 

lcterohaemorrhagiaeb

Verdun

human, 1917, France

Leptospira kirschneri

Grippotyphosa

Dadasa

Gr-01-005

kidney aborted piglet, 1983, USA

Leptospira kirschneri

 

Bananal/Lianguangb

11808

shrew, 1972, USA

Leptospira kirschrneri

 

Grippotyphosab

142

horse eye, 1997 Germany

Leptospira interrogans

Australis

Bratislavaa

As-05-073

pig placenta, 1989, USA

Leptospira interrogans

 

Bratislavab

X35lM-001

pig, 1990, USA

Leptospira interrogans

Pomona

Pomonaa

Po-01-000

human blood, 1937, Australia

Leptospira interrogans

 

Pomonab

02-0162

not known

Leptospira santarosai

Tarassovi

Gatunia

X345

human blood, 1938, Russia

Leptospira weilii

 

Vughiab

L100

pig kidney, 2001, China

Leptospira borgpetersenii

 

Tarassovib

Perepelitsin

human blood, 1941, Russia

avaccine strain

bchallenge strain

Notes

Declarations

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
MSD Animal Health

Reference

  1. Jacobs A, Harks F, Hoeijmakers M, Segers R. Porcine Health Manag. 2015;1:16.View ArticleGoogle Scholar

Copyright

© Jacobs et al. 2015

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