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Table 5 Bacterial pathogens isolated on days 0 and 7 from lower respiratory tract lesions, bronchoalveolar lavage and nasal swabs, minimum inhibitory concentrations (MIC) and susceptibilities to marbofloxacin and enrofloxacin

From: Randomised controlled field study to evaluate the efficacy and clinical safety of a single 8 mg/kg injectable dose of marbofloxacin compared with one or two doses of 7.5 mg/kg injectable enrofloxacin for the treatment of Actinobacillus pleuropneumoniae infections in growing-fattening pigs in Europe

  

Marbofloxacin

Enrofloxacin

MIC range

MIC50

MIC90

S%

n

MIC range

MIC50

MIC90

S%

n

A. pleuropneumoniae

Day 0

0.03–0.12

0.06

0.06

100

61

0.015–0.12

0.06

0.06

100

61

Day 7

nc

nc

nc

nc

0

nc

nc

nc

nc

0

H. parasuis

Day 0

0.25–2.0

0.015

0.06

n/a

18

0.004–1.0

0.015

0.03

n/a

13

Day 7

0.015

nc

nc

n/a

2

0.008

nc

nc

n/a

2

P. multocida

Day 0

0.008–0.03

0.015

0.03

100

32

0.004–0.015

0.008

0.015

100

32

Day 7

0.008–0.03

0.015

0.03

100

18

0.008–0.015

0.008

0.008

100

18

B. bronchiseptica

Day 0

0.25–1.0

0.5

0.5

n/a

92

0.25–0.5

0.5

0.5

n/a

92

Day 7

0.25–0.5

0.5

0.5

n/a

138

0.25–1.0

0.5

0.5

n/a

134

  1. MIC50, MIC90, lowest concentrations (μg/mL) of the antimicrobial for which 50 and 90% of the isolates were inhibited, respectively; n, total number of isolates from lung/lower respiratory tract, bronchoalveolar lavage and nasal swabs, combined, for which MIC was determined; n/a susceptibility data not available; nc, not calculated for <10 isolates; S, percentage of isolates within a species that were susceptible to the antimicrobial based on European susceptibility monitoring and where available CLSI breakpoints [28, 29, 38]