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Table 2 Distribution of animals by farm and treatment group, and homogeneity of clinical scores and rectal temperatures before treatment on day 0 (per protocol population)

From: Randomised controlled field study to evaluate the efficacy and clinical safety of a single 8 mg/kg injectable dose of marbofloxacin compared with one or two doses of 7.5 mg/kg injectable enrofloxacin for the treatment of Actinobacillus pleuropneumoniae infections in growing-fattening pigs in Europe

  

Marbofloxacin (T1)

Enrofloxacin (T2)

T1 vs. T2

P valuea

Farm site

Total no. animals

Mild

Moderate

Severe

Total no. animals

Mild

Moderate

Severe

Respiratory scores % [n]b

GA

36

0.0 [0]

97.2 [35]

2.8 [1]

35

0.0 [0]

100 [35]

0.0 [0]

0.324

GB

35

0.0 [0]

82.9 [29]

17.1 [6]

35

68.6 [24]

31.4 [11]

0.0 [0]

0.166

HA

24

0.0 [0]

100 [24]

0.0 [0]

24

0.0 [0]

100 [24]

0.0 [0]

nc

HB

26

0.0 [0]

100 [26]

0.0 [0]

24

0.0 [0]

95.8 [23]

4.2 [1]

0.298

Combined

121

0.0 [0]

94.2 [114]

5.8 [7]

118

0.0 [0]

89.8 [106]

10.2 [12]

0.193

Depression scores % [n]b

GA

36

97.2 [35]

2.8 [1]

0.0 [0]

35

97.1 [34]

2.9 [1]

0.0 [0]

0.984

GB

35

85.7 [30]

11.4 [4]

2.9 [1]

35

85.7 [30]

14.3 [5]

0.0 [0]

0.961

HA

24

70.8 [17]

29.2 [7]

0.0 [0]

24

83.3 [20]

16.7 [4]

0.0 [0]

0.308

HB

26

100 [0]

0.0 [0]

0.0 [0]

24

95.8 [23]

4.2 [1]

0.0 [0]

0.298

Combined

121

89.3 [108]

9.9 [12]

0.8 [1]

118

90.7 [107]

9.3 [11]

0.0 [0]

0.647

Rectal temperatures °C

GA

36

 

40.4 (0.047)

 

35

 

40.4 (0.049)

 

0.702

GB

35

 

40.6 (0.068)

 

35

 

40.6 (0.069)

 

0.556

HA

24

 

40.6 (0.114)

 

24

 

40.4 (0.060)

 

0.737

HB

26

 

40.7 (0.077)

 

24

 

40.9 (0.091)

 

0.240

Combined

121

 

40.6 (0.037)

 

118

 

40.6 (0.034)

 

0.603

  1. Farm site: Country identification G Germany, H Hungary. A and B indicate different farms within country
  2. Numbers of animals and percentages refer to the per protocol populations. Animals euthanised prior to study for diagnostic purposes are excluded from these populations
  3. aFor respiration and depression scores, p values are from Mantel-Haenszel mean score for each site separately and on Cochran-Mantel-Haenszel mean score statistic for combined
  4. bRefer to Clinical examinations for details of scoring. [n] number of animals. nc Not calculated
  5. Rectal temperatures shown as mean (standard error). For rectal temperatures, p values are based on Wilcoxon rank sum statistic for each site separately and on the extended Mantel-Haenszel statistic for combined