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Table 6 Classification of antibacterial drugs frequently used in the treatment of enteric colibacillosis according to pharmacokinetics and pharmacodynamics indices (modified from Ahmad et al. [41])

From: Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance

Drugs Bacterial effect PK/PD parameters
Fluoroquinolones (enrofloxacin) Concentration dependent Cmax/MIC and AUC/MIC
Cephalosporins (ceftiofur) Time dependent T > MIC
Sulphonamides + Diaminopyrimidines (trimethoprim + sulfamethoxazole) Time dependent T > MIC
Aminoglycosides (neomycin) Concentration dependent Cmax/MIC or AUC/MIC
Aminocyclitols (spectinomycin)   T > MIC
Polymyxins (colistin) Concentration dependent AUC/MIC