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Table 7 Main antimicrobials used in swine for the treatment of enteric colibacillosis: routes of administration, dosages and main pharmacokinetic properties (modified from Burch [37])

From: Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance

Antimicrobial class/compounds Administration and dosage (mg/kg body weight) Pharmacokinetic Properties Administration in enteric colibacillosis
Injection In water In feed
Trimethoprim/sulfonamide 15 (2.5 + 12.5) 30 (5 + 25) 15 (2.5 + 12.5) Rapidly absorbed from intestine,well distributed in tissues;crosses uninflamed blood–brain barrier IM and orally
Amoxicillin 7 20 15–20   IM and orally
Amoxicillin + Clavulanic acid 7 + 1,75     IM
Ceftiofur 3    Poorly absorbed from intestine,relatively poorly distributed intissues; crosses only inflamedblood–brain barrier IM
Cefquinome 1–2     IM
Enrofloxacin 2.5    Well absorbed and distributed intissues IM
Neomycin   11 11 Poorly absorbed from intestine,relatively poorly distributed intissues Orally
Apramycin   7.5–12.5 4–8 Poorly absorbed from intestine,relatively poorly distributed intissues Orally
Spectinomycin   10–50 1.1–2.2 Poorly absorbed from intestine,relatively poorly distributed intissues Orally
Colistin sulphate   100,000 IU/Kg body weight 100,000 IU/Kg body weight Not absorbed from intestine. Orally