Table 7 Main antimicrobials used in swine for the treatment of enteric colibacillosis: routes of administration, dosages and main pharmacokinetic properties (modified from Burch [37])
From: Swine enteric colibacillosis: diagnosis, therapy and antimicrobial resistance
Antimicrobial class/compounds | Administration and dosage (mg/kg body weight) | Pharmacokinetic Properties | Administration in enteric colibacillosis | ||
|---|---|---|---|---|---|
Injection | In water | In feed | |||
Trimethoprim/sulfonamide | 15 (2.5 + 12.5) | 30 (5 + 25) | 15 (2.5 + 12.5) | Rapidly absorbed from intestine,well distributed in tissues;crosses uninflamed blood–brain barrier | IM and orally |
Amoxicillin | 7 | 20 | 15–20 |  | IM and orally |
Amoxicillin + Clavulanic acid | 7Â +Â 1,75 | Â | Â | Â | IM |
Ceftiofur | 3 |  |  | Poorly absorbed from intestine,relatively poorly distributed intissues; crosses only inflamedblood–brain barrier | IM |
Cefquinome | 1–2 |  |  |  | IM |
Enrofloxacin | 2.5 | Â | Â | Well absorbed and distributed intissues | IM |
Neomycin | Â | 11 | 11 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally |
Apramycin |  | 7.5–12.5 | 4–8 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally |
Spectinomycin |  | 10–50 | 1.1–2.2 | Poorly absorbed from intestine,relatively poorly distributed intissues | Orally |
Colistin sulphate | Â | 100,000Â IU/Kg body weight | 100,000Â IU/Kg body weight | Not absorbed from intestine. | Orally |