Table 3 Criteria for euthanasia of animals prior to end of study

E1

Respiratory score of 3

E2

Depression score of 3

E3

Rectal body temperature > 42.0 °C

E4

Rectal body temperature < 37.5 °C and respiratory score > 1

E5

Rectal body temperature < 37.5 °C and depression score > 1

E6

Rectal body temperature > 40.3 °C and respiratory score > 1 on more than 2 consecutive days after day 3 post inoculation

E7

Rectal body temperature > 40.3 °C and depression score > 1 on more than 2 consecutive days after day 3 post inoculation

E8

Any unpredictable event, reaction to treatment or disease leading to a moderate to severe reduction of general condition for more than 48 h

E9

Any unpredictable event, reaction to treatment or disease inducing pain for more than 48 h