Table 1 Recombinant LAVs tested in vivo, specially indicating those providing protection again the Genotype II virus currently circulating in Asia and Europe (bolded data)
From: African swine fever vaccines: a promising work still in progress
Deleted gene(s) | Protein(s) | Parental ASFV | Recombinant LAVs | Target cells | Reference | ||
|---|---|---|---|---|---|---|---|
Strain | Virulence | Virulence | Protection | ||||
EP402R | CD2v | BA71V | Non-pathogenic | Non-pathogenic | None | Vero | [45] |
Malawi Lil-20/1 | Virulent | Virulent | None | Macrophages | [46] | ||
Georgia2010 | Virulent | Virulent | None | Macrophages | [47] | ||
BA71 | Virulent | Attenuated | BA71, E75, Georgia2007/1 | COS-1 & Macrophages | [48] | ||
DP71L | NL | Malawi Lil-20/1 | Vrulent | Virulent | Malawi | Macrophages | |
E70 | Virulent | Attenuated | E70 | Macrophages | |||
B119L | 9GL | Pretoriuskop/96/4 | Virulent | Attenuated | Pretoriuskop/96/4 | Macrophages | [52] |
Malawi Lil-20/1 | Virulent | Attenuated | Malawi | Macrophages | [53] | ||
Georgia2010 | Virulent | Attenuated | Georgia2010 | Macrophages | [54] | ||
DP96R | UK | E70 | Virulent | Attenuated | E70 | Macrophages | [55] |
DP148R | Benin | Virulent | Attenuated | Benin | Macrophages | [56] | |
MGF360 & MGF505 | Benin | Virulent | Attenuated | Benin | Macrophages | [57] | |
Georgia2010 | Virulent | Attenuated | Georgia2010 | Macrophages | [58] | ||
B119L & DP96R | 9GL & UK | Georgia2010 | Virulent | Attenuated | Georgia2010 | Macrophages | [59] |
MGF360 & MGF505 & B119L | Georgia2010 | Virulent | Highly attenuated | None | Macrophages | [60] | |
B119L & DP96R & DP71L | 9GL & UK & NL | Georgia2010 | Virulent | Highly attenuated | None | Macrophages | [61] |
DP71L & DP96R | NL & UK | OUR T88/3 | Attenuated | Highly attenuated | None | Macrophages | [62] |
A238L A224L EP153R | NFAT regulator Apoptosis inhibitor MHC-I antigen presenting modulator | NH/P68 | Attenuated | Highly attenuated | L60 | COS-7 & Macrophages | [63] |
MGF360 & MGF505 & EP402R | MGF505-1R, MGF505-2R, MGF505-3R, MGF360-12 L, MGF360-13 L, MGF360-14 L & CD2v | China HLJ/18 | Virulent | Attenuated | China HLJ/18 | Macrophages | [64] |