Efficacy of a novel intradermal Lawsonia intracellularis vaccine in pigs against experimental infection and under field conditions

Table 2 Post-challenge results ± SD of vaccination-challenge studies 1 and 2

vaccine group	avg clinical score day 13-21	ADWG g/day day 13-20	PCR faeces avg log pg DNA/μl		PCR mucosa avg log pgDNA/μl day 21	avg macroscopic ileum score day 21	avg microscopic ileum score (IHC) day 21
vaccine group	avg clinical score day 13-21	ADWG g/day day 13-20	AUC	day 21	PCR mucosa avg log pgDNA/μl day 21	avg macroscopic ileum score day 21	avg microscopic ileum score (IHC) day 21
Study 1: vaccination at 3 weeks of age, challenge at 7 weeks of age, necropsy 21 days after challenge
Law ID^a	0.3 ± 0.5	956 ± 119^d,e	0.13 ± 44^d,e	0.0 ± 0.0^d,e	0.03 ± 0.04^d,e	0.6 ± 1.5^d,e	0.1 ± 0.3^d,e
Live vaccine^b	0.2 ± 0.4	812 ± 287	0.79 ± 0.91^d	0.77 ± 0.81	0.50 ± 0.51	61 ± 81	3.4 ± 3.2^d
Control	0.5 ± 1.0	674 ± 381	1.44 ± 1.13	0.73 ± 0.93	0.66 ± 0.60	68 ± 125	5.7 ± 3.3
Study 2: vaccination at 3 weeks of age, challenge at 24 weeks of age, necropsy 21 days after challenge
Law ID + PCV ID^c	1.3 ± 1.9^d	1001 ± 710^d	4.23 ± 1.51	0.71 ± 0.96^d	0.19 ± 43^d	129 ± 165^d	2.9 ± 2.8^d
Control	3.8 ± 5.4	-139 ± 1210	5.02 ± 1.65	1.90 ± 1.08	0.54 ± 61	241 ± 160	7.7 ± 2.6

ISSN: 2055-5660