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Table 1 Overview of clinical signs, pathohistologic and diagnostics findings

From: Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series

Farm Piglet CNS-related clinical signs Pathohistologic lesions of the brain Mhr isolation from different tissues other bacteria isolated from CNS samples PRRSV status of farms and PCR results of piglets PCV-2 PCR results of piglets
1 A lateral recumbency, reduced general behavior none serosa +++ meninges +/++ synovia +++ PRRSV detected in tissue samples by RT-PCR below limit of quantification
B head tilt severe lymphocytic and fibrinopurulent leptomeningitis serosa +++ meninges +/++ synovia +++ PRRSV detected in tissue samples by RT-PCR below limit of quantification
2 A head tilt, reduced general behavior none CSF +++ serosa +++ PRRSV detected in tissue samples by RT-PCR negative
B none none serosa +++ no samples taken PRRSV detected in tissue samples by RT-PCR negative
3 A lateral recumbency, unable to rise severe fibrinopurulent leptomeningitis CSF (+) lung +++ synovia (+) CSF: S. suis + MLV vaccinated, not tested negative
B uncoordinated movement, lameness, tremor/shaking moderate fibrinopurulent leptomeningitis CSF (+) MLV vaccinated, not tested negative
C uncoordinated movement, lameness, tremor/shaking severe fibrinopurulent leptomeningitis CSF ++/+++ lung tissue (+) MLV vaccinated, not tested negative
4 A peracute deaths, no symptoms severe fibrinopurulent leptomeningitis meninges (+) lung (+) unsuspicious, not tested negative
B peracute deaths, no symptoms severe fibrinopurulent leptomeningitis meninges ++ lung + unsuspicious, not tested negative
  1. Abbreviations: CNS central nervous system, Mhr Mycoplasma hyorhinis, PRRSV procine reproductive and respiratory syndrome virus, PCV2 porcine circovirus 2, CSF cerebrospinal fluid. MLV modified life virus, S. Streptococcus, − negative, (+) scant growth, + light growth, ++ moderate growth, +++ heavy growth