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Table 1 Overview of clinical signs, pathohistologic and diagnostics findings

From: Mycoplasma hyorhinis as a possible cause of fibrinopurulent meningitis in pigs? - a case series

Farm

Piglet

CNS-related clinical signs

Pathohistologic lesions of the brain

Mhr isolation from different tissues

other bacteria isolated from CNS samples

PRRSV status of farms and PCR results of piglets

PCV-2 PCR results of piglets

1

A

lateral recumbency, reduced general behavior

none

serosa +++ meninges +/++ synovia +++

PRRSV detected in tissue samples by RT-PCR

below limit of quantification

B

head tilt

severe lymphocytic and fibrinopurulent leptomeningitis

serosa +++ meninges +/++ synovia +++

PRRSV detected in tissue samples by RT-PCR

below limit of quantification

2

A

head tilt, reduced general behavior

none

CSF +++ serosa +++

PRRSV detected in tissue samples by RT-PCR

negative

B

none

none

serosa +++

no samples taken

PRRSV detected in tissue samples by RT-PCR

negative

3

A

lateral recumbency, unable to rise

severe fibrinopurulent leptomeningitis

CSF (+) lung +++ synovia (+)

CSF: S. suis +

MLV vaccinated, not tested

negative

B

uncoordinated movement, lameness, tremor/shaking

moderate fibrinopurulent leptomeningitis

CSF (+)

MLV vaccinated, not tested

negative

C

uncoordinated movement, lameness, tremor/shaking

severe fibrinopurulent leptomeningitis

CSF ++/+++ lung tissue (+)

MLV vaccinated, not tested

negative

4

A

peracute deaths, no symptoms

severe fibrinopurulent leptomeningitis

meninges (+) lung (+)

unsuspicious, not tested

negative

B

peracute deaths, no symptoms

severe fibrinopurulent leptomeningitis

meninges ++ lung +

unsuspicious, not tested

negative

  1. Abbreviations: CNS central nervous system, Mhr Mycoplasma hyorhinis, PRRSV procine reproductive and respiratory syndrome virus, PCV2 porcine circovirus 2, CSF cerebrospinal fluid. MLV modified life virus, S. Streptococcus, − negative, (+) scant growth, + light growth, ++ moderate growth, +++ heavy growth