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Table 2 Interference of maternally derived antibodies (MDA) with vaccine efficacy in terms of serological and production parameters

From: Impact of maternally derived immunity on immune responses elicited by piglet early vaccination against the most common pathogens involved in porcine respiratory disease complex

Pathogen

Vaccination age (in weeks)

Interference on antibody seroconversion (assay used)a

Interference on production parameters (parameters evaluated)b

References

SIV

3

Yes (HI assay)

NE

[23]

 

Different age groups

Yes (HI assay)

NE

[67]

 

16

Yes (HI assay, ELISA)

NE

[68]

PRRSV

3

Yes (ELISA, VNT)

NE

[71]

 

3 & 4

Yes (ELISA)

NE

[82]

PCV-2

4

Yes (ELISA)

No (ADWG)

[96]

 

3

NE

No (ADWG)

[93]

 

3

Yes (IPMA, VNT)

NE

[17]

 

3

Yes (ELISA)

NE

[95]

 

3

Yes (IPMA)

NE

[97]

 

4

Yes (IPMA)

No (ADWG)

[98]

 

Different age groups

Yes (ELISA)

Yes (ADWG)

[99]

 

4

Yes (ELISA)

NE

[60]

 

3

Yes (ELISA)

Only when S/P values at vaccination are extremelly high (ADWG)

[21]

 

2

NE

No (ADWG, mortality)

[100]

M. hyopneumoniae

1 & 4

Yes (ELISA)

No (ADWG, mortality)

[115]

 

2

Yes (ELISA)

NE

[112]

 

1 & 4

Yes (NC)

NE

[114]

 

1

No (ELISA)

NE

[109]

 

1

No (ELISA)

NE

[111]

 

1

Yes (ELISA)

NE

[116]

 

1

Yes (ELISA)

NE

[113]

A. pleuropneumoniae

6

Yes (ELISA)

NE

[128]

 

6

Yes (ELISA)

NE

[123]

  1. a“Yes” when the age and/or MDA of the animals of study are associated with reduced/retarded active antibody post-vaccinal response; “No” when the age and/or MDA of the animals of study are not attributed to a reduced/retarded active antibody post-vaccinal response; “NE” when serologic parameters are not evaluated. HI assay: Hemagglutination-inhibition assay; VNT: Virus neutralisation test; ELISA: Enzyme-linked immunosorbent assay; IPMA: Immunoperoxidase monlayer assay; NC: Not cited
  2. bNE Not evaluated; ADWG Average daily weight gain