Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Cui, Yiyan; Tian, Zhimei; Yu, Miao; Deng, Dun; Lu, Huijie; Song, Min; Ma, Xianyong; Wang, Limin

doi:10.1186/s40813-022-00269-8

Porcine Health Management

Table 3 Effects of guanidinoacetic acid (GAA) on plasma free amino acid profile in finishing pigs (nmol/mL)

From: Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Items	GAA, mg/kg				SEM	P-value
Items	0	500	1000	1500	SEM	ANOVA	Linear	Quadratic
EAA
Methionine	35.50	39.00	34.83	31.60	3.13	0.476	0.310	0.300
Threonine	128.33	141.00	138.67	114.60	9.56	0.286	0.413	0.083
Valine	224.67	243.33	236.83	191.00	15.24	0.132	0.179	0.051
Isoleucine	77.83	87.33	87.50	71.60	5.29	0.170	0.567	0.035
Leucine	195.67^ab	205.67^a	184.50^ab	164.60^b	8.25	0.017	0.008	0.081
Phenylalanine	75.00	78.17	73.17	67.20	3.46	0.202	0.096	0.196
Tryptophan	62.17	52.83	61.67	39.60	6.91	0.137	0.100	0.398
Lysine	192.17	183.83	193.67	146.60	12.86	0.130	0.086	0.205
Histidine	89.00	83.17	88.33	78.60	3.68	0.293	0.202	0.663
Arginine	147.33	136.83	142.50	129.20	7.49	0.515	0.240	0.888
NEAA
Serine	122.33	118.83	108.83	99.80	7.57	0.228	0.046	0.728
Glycine	914.33^a	863.00^ab	845.33^ab	727.00^b	35.63	0.014	0.002	0.367
Alanine	354.00	342.83	341.00	361.40	17.96	0.843	0.807	0.394
Glutamate	74.83	84.83	80.83	74.60	7.38	0.748	0.939	0.307
Glutamine	233.00	256.17	261.83	252.60	17.11	0.689	0.415	0.384
Aspartic acid	17.40	15.50	21.67	15.80	2.48	0.393	0.850	0.498
Asparagine	30.50	35.75	44.83	31.40	4.81	0.270	0.554	0.104
Tyrosine	84.50	83.17	92.50	86.80	4.98	0.596	0.506	0.700
Proline	239.67	215.33	226.33	211.00	12.34	0.392	0.203	0.704
Non-protein amino acids and derivatives/ metabolites of amino acids
Ornithine	59.17^ab	67.00^a	61.17^ab	50.40^b	3.57	0.033	0.079	0.016
Taurine	86.17	97.00	103.67	81.80	5.89	0.120	0.971	0.025
Citrulline	74.00	74.17	74.17	69.00	5.03	0.884	0.561	0.620
Hydroxyproline	101.00	127.00	133.67	126.00	16.34	0.570	0.296	0.352
Cystathionine	5.50	9.00	8.20	7.25	0.92	0.130	0.174	0.067
α-aminoadipic acid	39.67	37.67	43.00	39.00	2.94	0.822	0.864	0.829
1-Methyl-L-histidine	12.40	15.00	15.80	11.00	1.84	0.309	0.704	0.078
Urea	4261.33	4247.67	4330.50	3845.40	432.94	0.869	0.589	0.597
∑EAA	1165.50	1198.33	1180.00	995.00	47.30	0.061	0.053	0.054
∑NEAA	2053.17	1988.00	2001.50	1844.60	61.50	0.165	0.051	0.483
TAA	3671.17^ab	3674.5^ab	3695.67^a	3273.2^b	103.51	0.036	0.032	0.058

SEM standard error of the mean, EAA essential amino acids, NEAA nonessential amino acids, TAA total amino acids
Dietary treatments were: basal diet + 0, 500, 1000, and 1500 mg/kg GAA, respectively. n = 6
^{a, b}Mean within rows with different letters differ significantly (P < 0.05)
Bold indicates P < 0.05

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ISSN: 2055-5660

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