Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Cui, Yiyan; Tian, Zhimei; Yu, Miao; Deng, Dun; Lu, Huijie; Song, Min; Ma, Xianyong; Wang, Limin

doi:10.1186/s40813-022-00269-8

Porcine Health Management

Table 6 Effects of guanidinoacetic acid (GAA) on renal free amino acid profile in finishing pigs (mg/kg dry kidney)

From: Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Items	GAA, mg/kg				SEM	P-value
Items	0	500	1000	1500	SEM	ANOVA	Linear	Quadratic
EAA
Methionine	0.13	0.17	0.16	0.13	0.02	0.278	0.700	0.063
Threonine	7.15	8.36	8.25	7.54	0.61	0.504	0.717	0.151
Valine	8.36	9.73	9.19	8.68	0.74	0.639	0.909	0.249
Isoleucine	4.21	4.60	4.54	3.94	0.36	0.594	0.621	0.208
Leucine	16.29	17.78	17.25	15.63	1.31	0.705	0.692	0.280
Phenylalanine	7.61	8.79	8.30	7.03	0.65	0.317	0.479	0.091
Tryptophan	11.57	12.18	11.68	11.83	1.10	0.983	0.957	0.845
Lysine	9.24	11.16	10.61	9.09	0.93	0.364	0.820	0.089
Histidine	3.20	3.98	3.91	3.87	0.30	0.332	0.203	0.229
Arginine	6.27	7.89	7.04	5.74	0.64	0.158	0.430	0.043
NEAA
Serine	10.53	12.28	12.22	10.54	1.04	0.503	0.993	0.135
Glycine	24.22	30.83	32.64	26.40	2.37	0.080	0.446	0.015
Alanine	17.67	19.34	19.89	17.81	1.35	0.646	0.883	0.219
Glutamate	37.40^b	49.99^a	47.15^ab	37.96^b	2.59	0.010	0.930	0.001
Glutamine	0.51	0.81	0.77	0.52	0.13	0.270	0.997	0.055
Aspartic acid	10.46	11.91	11.50	10.82	0.91	0.709	0.879	0.279
Asparagine	3.78	4.59	5.04	4.64	0.42	0.263	0.139	0.188
Cystine	3.21^b	9.00^a	6.69^ab	3.02^b	1.35	0.017	0.646	0.003
Tyrosine	6.96	8.17	7.51	6.57	0.60	0.329	0.526	0.103
Proline	19.25^a	22.25^a	18.07^a	8.68^b	1.96	0.002	0.001	0.009
Non-protein amino acids and derivatives/metabolites of amino acids
Ornithine	1.34	1.77	1.85	1.68	0.16	0.173	0.150	0.087
Taurine	31.65	34.05	32.50	35.24	2.04	0.673	0.364	0.941
Citrulline	1.02	1.01	1.04	1.00	0.03	0.900	0.827	0.622
β-alanine	1.69	1.71	1.49	1.54	0.10	0.550	0.251	0.895
Hydroxyproline	1.18	1.49	1.10	1.35	0.18	0.543	0.869	0.946
Cystathionine	7.79	8.86	8.39	7.50	0.67	0.517	0.670	0.170
α-aminoadipic acid	5.44	3.75	4.81	8.62	1.15	0.089	0.089	0.051
γ-amino-n-butyric acid	0.36^b	0.46^ab	0.45^ab	0.53^a	0.04	0.039	0.008	0.793
Urea	26.94	32.75	19.66	27.93	6.21	0.561	0.729	0.851
Ammonia	1.84^a	1.93^a	1.58^ab	0.96^b	0.15	0.001	0.000	0.036
∑EAA	74.01	84.58	80.92	73.42	6.04	0.558	0.852	0.177
∑NEAA	184.98	222.48	213.45	184.42	12.15	0.131	0.861	0.023
TAA	258.13	306.04	293.71	256.84	18.05	0.222	0.856	0.045

SEM standard error of the mean, EAA essential amino acids, NEAA nonessential amino acids, TAA total amino acids
Dietary treatments were: basal diet + 0, 500, 1000, and 1500 mg/kg GAA, respectively. n = 6
^{a, b}Mean within rows with different letters differ significantly (P < 0.05)
Bold indicates P < 0.05

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ISSN: 2055-5660

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