Fig. 3

Lymphohistiocytic meningoencephalitis and necrotic myositis due to PCV-2 associated disease in pigs. a Telencephalic cortex. Moderate perivascular inflammatory infiltrate of lymphocytes and plasma cells segmentally expanding the leptomeninges, sometimes forming small perivascular aggregates (asterisk), accompanied by mild hemorrhage. Areas with accumulations of rare lymphocytes and multinucleated giant cells are observed in the adjacent neuropil (arrow). HE. × 40. b Area with mild infiltrate of lymphocytes, multinucleated giant cells, and glial cells (arrow), adjacent to a blood vessel. HE. × 200. c Skeletal muscle with marked diffuse necrosis, with intense vasculitis (arrow), and multifocal interstitial inflammatory infiltrate. HE. × 40. d Skeletal muscle with marked diffuse biphasic necrosis (asterisk), with intense vasculitis (arrow), and multifocal inflammatory infiltrate of neutrophils and lymphocytes, accompanied by interstitial hemorrhage. HE. × 100