Table 4 The top 5 downregulated gene transcription fold changes relative to the positive control for each treatment in response to LPS challenge or no challenge for the Negative control were compiled
Positive control | MRF | Product A | Product B | Product C | Negative control | gene_name | Description |
|---|---|---|---|---|---|---|---|
1 | 0.166 | 0.166 | 0 | 0 | 6 | ACR | Serine proteinase with trypsin-like specificity |
1 | 0.142 | 0.571 | 0 | 0 | 7 | CNTN5 | Mediate cell surface interactions during nervous system development |
1 | 0 | 0.428 | 0.285 | 0 | 7 | CREG2 | Roles in oxidoreductase activity and FMN binding |
1 | 1 | 10 | 0 | 0 | 0.25 | DOCK10 | Dedicator of cytokinesis protein 10 involved in intracellular signalling networks |
1 | 0 | 0 | 0.2 | 0.6 | 5 | GPR4 | A pro-inflammatory G protein-coupled receptor (GPCR) highly expressed in vascular endothelial cells |
1 | 0 | 0 | 0 | 0 | 6 | GATA5 | Cooperative function in the activation of the intestinal lactase-phlorizin hydrolase promoter |
1 | 6 | 0 | 3 | 1 | 0 | GRID1 | Glutamate receptor ligand-gated ion channel |
1 | 0 | 2 | 5 | 0 | 0 | LRRC14B | Leucine Rich Repeat Containing 14B |
1 | 0 | 0 | 0 | 0 | 6 | NPSR1 | Membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes and associated with inflammatory bowel disease |
1 | 1 | 0 | 0 | 6 | 0 | SLCO1A2 | Mediates cellular uptake of a wide range of endogenous substrates |
1 | 0 | 6 | 0 | 1 | 0 | SV2B | control of regulated secretion in neural and endocrine cells |
1 | 6 | 0 | 1 | 1 | 0 | TDRD9 | Required for transposon silencing in the nucleus |
1 | 0 | 0.428 | 0 | 0 | 7 | TRPM3 | Non-selective calcium cation channel |