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Table 4 ASFV subunit vaccines tested in vivo that induced some level of protection

From: African swine fever vaccines: a promising work still in progress

Gene Name Immunization Challenge strain Outcome Haplotype Reference
A179L, B407L, B438L, B602L, B646L, Complement (183875–184,183), CP204L, CP2475L, CP530R, D117L, D339L, DP71L, E120R, E183L, E199L, EP153R, EP364R, EP402R, F1055L, F317L, G1211R, G1340L, H108R, I329L, K205R, KP177R, L10L, M1249L, MGF110-2 L, MGF110-4 L, MGF300-2R, MGF360-11 L, MGF360-15R, MGF360-18R, MGF360-1 L, MGF505-4R, MGF505-5R, NP1450L, NP419L & O61R DNA prime + rVACV boost Georgia 2007/1 No surviving pigs
Reduced viremia and viral loads in some tissues
Babraham [73]
B646L, CP204L, CP2475L (p37, p150), CP530R & E183L rAd Georgia 2007/1 Partial protection: 5/9 surviving pigs versus 1/5 control pigs
Reduced viremia depending on the adjuvant used
Pigs recover from infection
Authors claim that none of the immunogens conferred statistically significant protection
Outbred [71, 81]
A151R, B646L, C129R, CP204L, CP530R, E146L, I215L, I73R, L8L, M448R, MGF110-4 L & MGF110-5 L rAd prime + MVA boost OUR T88/1 No surviving pigs
3/6 pigs with reduced and delayed clinical signs, 5/6 pigs with reduced viremia
Reduced viral load in some tissues
Outbred [38]
CP2475L & A137R Synthetic peptides E70 No surviving pigs
Increased average survival
Reduced mean viral titers
Outbred [72]
CP204L & B646L Synthetic peptides E70 No surviving pigs
Increased average survival
Reduced mean viral titers
Outbred [72]
CP204L, E183L & EP402 DNA (as a fusion with Ub) E75 Partial protection: 2/6 surviving pis
Delayed clinical signs and viremia
Pigs recover from the infection
Outbred [89]
CP312R DNA expression library E75 Partial protection: 6/10 surviving pigs
Reduced virus titers in blood, shedding and lesions
Pigs recover from the infection
Outbred [91, 94]