Table 4 Combined inactivation steps in the manufacturing process of SDP. Inactivation expressed as colony-forming unit (cfu) per g in case of bacteria and Log10 TCID50 for viruses
Bacteria /Virus (enveloped or non-enveloped) | Spray-Drying | Reference | UV-C | Reference | Storage at 20 °C for 14 d | Reference | Combined Theoretical Inactivation |
|---|---|---|---|---|---|---|---|
E. coli K88 | 7.3 | [30] | 4.3 | [30] | Â | Â | 11.6 |
E. coli K99 | 7.7 | [30] | 4 | [30] | Â | Â | 11.7 |
Salmonella typhimurium | 5.4 | [29] | 3.6 | [72] | > 4.2 | [29] | > 13.2 |
Salmonella choleraesuis | 5.3 | [29] | 5.6 | [72] | > 4.8 | [29] | > 15.7 |
PRV (enveloped) | > 5.3 | [31] | 4.5 | [74] |  |  | > 9.8 |
PRRSV (enveloped) | > 4.0 | [31] | > 4.0 | [74] | > 4.0 | [47] | > 12.0 |
PEDV (enveloped) | > 5.2 | [34] | > 4.1 | [74] | > 3.5 | [34] | > 12.8 |
ASFV (enveloped) | ~ 4.0 | [35] | ~ 4.0 | [75] |  |  | ~ 8.0 |
SVDV (non-enveloped) | > 6.0 | [32] | 2.6 | [74] |  |  | > 8.6 |