Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigs

Table 1 Treatment efficacy of tylvalosin (TVN) and tylosin (TYL) against natural outbreaks of enzootic pneumonia associated with M. hyopneumoniae in Hungary and France

Study	n	Day 0 clinical cases n (% of total)	Treatment success on study completion^a
Study	n	Day 0 clinical cases n (% of total)	n (%)	Group comparison p-values	Non inferiority p-values^b
Hungary
TVN	255	12 (4.7%)	11 (91.7%)	1.00	0.04
TYL	241	15 (6.2%)	13 (86.7%)	1.00	0.04
France
TVN	183	18 (9.8%)	13 (72.2%)	0.01	< 0.01
TYL	182	24 (13.2%)	6 (25.0%)	0.01	< 0.01
Both sites combined
TVN	438	30 (6.8%)	24 (80.0%)	0.03	< 0.01
TYL	423	39 (9.2%)	19 (48.7%)	0.03	< 0.01

M. hyopneumoniae and other bacteria including P. multocida were isolated at both sites prior to Day 0
n Number of pigs
^aAbsence of treatment failures and relapses through to Day 13
^bNon-inferior to control product (Farrington Manning p ≤ 0.05 indicates non inferiority to control product)

ISSN: 2055-5660