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Table 1 Treatment efficacy of tylvalosin (TVN) and tylosin (TYL) against natural outbreaks of enzootic pneumonia associated with M. hyopneumoniae in Hungary and France

From: Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigs

Study n Day 0 clinical cases
n (% of total)
Treatment success on study completiona
n (%) Group comparison
p-values
Non inferiority
p-valuesb
Hungary
 TVN 255 12 (4.7%) 11 (91.7%) 1.00 0.04
 TYL 241 15 (6.2%) 13 (86.7%)
France  
 TVN 183 18 (9.8%) 13 (72.2%) 0.01 < 0.01
 TYL 182 24 (13.2%) 6 (25.0%)
Both sites combined  
 TVN 438 30 (6.8%) 24 (80.0%) 0.03 < 0.01
 TYL 423 39 (9.2%) 19 (48.7%)
  1. M. hyopneumoniae and other bacteria including P. multocida were isolated at both sites prior to Day 0
  2. n Number of pigs
  3. aAbsence of treatment failures and relapses through to Day 13
  4. bNon-inferior to control product (Farrington Manning p ≤ 0.05 indicates non inferiority to control product)