Table 7 The detection of eleven hub genes and the protein-protein network
No. | Gene in node1 | Combined gene numbers | Genes in the node 2 |
|---|---|---|---|
1 | COX1 | 35 | AICDA,ATP6,ATP8,CAT,COX17,COX18,COX2,COX3,COX5A,COX5B,COX6A1,CYCS,CYTB,EXO1,HFM1,HSPA9,HSPD1,MRPS7,MT-ND2,ND1,ND3,ND4,ND4L,ND5,ND6,NDUFS2,NRF1,PNOC,POLD1,RAG2,REEP5,SDHC,SOD2,TCTP,UBC |
2 | COX3 | 23 | AICDA,ATP6,ATP8,COX1,COX2,COX5A,COX5B,COX6A1,CYCS,CYTB,HIGD1A,MT-ND2,ND1,ND3,ND4,ND4L,ND5,ND6,NDUFS2,PNOC,RPS12,SDHC,SOD2 |
3 | CYP11A1 | 17 | AR,CEL,CYB5A,CYP21A2,DHCR24,DHRS11,FSHR,GNRH1,HSD11B2,HSD17B1,HSD17B6,HSD17B7,HSD3B1,LIPA,SCARB1,SOAT1,STAR |
4 | DHRS4 | 20 | ACOT4,ALDH1A1,ALDH1A2,ARHGAP11A,CAT,CYB5A,CYTH4,DAO1,ECH1,EPHX2,GSTO2,HSD17B2,HSD17B4,IDH1,KIF4A,PECR,RDH12,RDH16,RETSAT,STX12 |
5 | HSD3B1 | 20 | CYB5A,CYP11A1,CYP21A2,CYP51,DHCR7,DHRS11,FDFT1,FSHR,HSD11B2,HSD17B1,HSD17B2,HSD17B4,HSD17B6,HSD17B7,LSS,MSMO1,SC5D,SQLE,STAR,TM7SF2 |
6 | MSMO1 | 25 | ACAT1,ACAT2,COL6A5,CPOX,CYB5A,CYP51,DHCR24,DHCR7,FDFT1,FDPS,HMGCR,HMGCS1,HSD17B12,HSD17B7,HSD3B1,INSIG1,LSS,MVK,NSDHL,SC5D,SCD,SCD5,SQLE,STARD4,TM7SF2 |
7 | NR4A1 | 13 | AR,ATF3,DUSP1,EGR1,EGR2,FOS,GRASP,MAPK3,NOR-1,PCK1,RPS6KA3,RTN4,VEGFA |
8 | PTX3 | 20 | ARMC8,ASAH1,C1QA,C1QC,CEP290,CFP,CST3,CSTB,CTSH,CTSZ,F3,GGH,IDH1,NEU1,QPCT,SELP,TIMP2,TNFAIP6,VEGFA,YPEL5 |
9 | RLN | 12 | ADCY4,ADCY9,ADM,ADORA2B,ADRB1,FSHR,HTR4,KIAA1109,PTHLH,RAMP2,RLF,RXFP4 |
10 | SCARB1 | 16 | ABCA1,ABCG5,APOA1,CD63,CD81,CD82,CYP11A1,EPHA2,HMGCR,LDLR,OLR1,PLTP,PPARA,PPARG,STAR,TSPAN3 |
11 | STAR | 17 | ADCY9,AR,CYP11A1,CYP21A2,DHRS11,FSHR,GBA,GBI1,GNRH1,HSD17B1,HSD17B6,HSD3B1,SCARB1,STARD4,TSPO2,UGT8,VDAC1 |