Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Cui, Yiyan; Tian, Zhimei; Yu, Miao; Deng, Dun; Lu, Huijie; Song, Min; Ma, Xianyong; Wang, Limin

doi:10.1186/s40813-022-00269-8

Porcine Health Management

Table 9 Effects of guanidinoacetic acid (GAA) on splenic free amino acid profile in finishing pigs (mg/kg dry spleen)

From: Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs

Items	GAA, mg/kg				SEM	P-value
Items	0	500	1000	1500	SEM	ANOVA	Linear	Quadratic
EAA
Methionine	0.09	0.07	0.20	0.19	0.01	0.002	0.001	0.491
Threonine	3.28^b	3.40^b	5.17^a	4.82^a	0.16	< 0.001	< 0.001	0.159
Valine	4.70^b	4.63^b	7.31^a	7.14^a	0.18	< 0.001	< 0.001	0.695
Isoleucine	1.56^b	1.57^b	2.42^a	2.32^a	0.06	< 0.001	< 0.001	0.398
Leucine	12.16^b	11.77^b	18.51^a	18.96^a	0.54	< 0.001	< 0.001	0.538
Phenylalanine	4.48^b	4.39^b	6.82^a	6.76^a	0.19	< 0.001	< 0.001	0.965
Tryptophan	1.82^b	1.83^b	9.26^a	9.10^a	0.36	< 0.001	< 0.001	0.706
Lysine	5.24^b	5.26^b	7.82^a	7.11^a	0.29	< 0.001	< 0.001	0.208
Histidine	1.96^c	1.90^c	2.93^a	2.57^b	0.09	< 0.001	< 0.001	0.087
Arginine	4.14^b	3.98^b	6.29^a	5.63^a	0.21	< 0.001	< 0.001	0.287
NEAA
Serine	4.41^b	4.58^b	7.05^a	6.77^a	0.21	< 0.001	< 0.001	0.312
Glycine	14.67^b	14.54^b	20.31^a	17.07^ab	0.97	0.007	0.025	0.179
Alanine	6.29^b	6.54^b	9.04^a	9.36^a	0.35	< 0.001	< 0.001	0.987
Glutamate	35.20^b	33.73^b	44.92^a	36.18^b	1.83	0.004	0.148	0.079
Glutamine	0.48^b	0.43^b	1.06^a	1.06^a	0.05	< 0.001	< 0.001	0.700
Aspartic acid	10.45^bc	9.40^c	15.11^a	12.54^ab	0.73	< 0.001	0.002	0.270
Asparagine	1.90^b	1.93^b	2.92^a	2.56^a	0.12	< 0.001	< 0.001	0.127
Cystine	0.19	0.24	0.23	0.23	0.04	0.895	0.691	0.597
Tyrosine	3.40^b	3.39^b	5.08^a	5.06^a	0.16	< 0.001	< 0.001	0.906
Proline	3.05^b	2.71^b	5.24^a	5.20^a	0.22	< 0.001	< 0.001	0.639
Non-protein amino acids and derivatives/metabolites of amino acids
Ornithine	0.08	0.09	0.08	0.13	0.04	0.901	0.530	0.774
Taurine	31.59	31.81	33.36	37.29	1.77	0.171	0.044	0.352
Citrulline	0.27	0.26	0.28	0.35	0.03	0.250	0.085	0.295
β-alanine	0.49	0.35	0.44	0.42	0.06	0.571	0.771	0.366
Cystathionine	5.10^b	5.01^b	7.55^a	8.15^a	0.25	< 0.001	< 0.001	0.245
α-aminoadipic acid	1.70^b	1.80^ab	2.05^ab	2.24^a	0.11	0.017	0.002	0.718
α-amino-n-butyric acid	0.81	0.81	1.12	0.84	0.14	0.403	0.592	0.351
β-aminoisobutyric acid	1.23^b	1.23^b	1.42^ab	1.68^a	0.09	0.012	0.002	0.199
Phosphoethanolamine	11.92^ab	9.92^b	17.43^a	14.03^ab	1.38	0.009	0.044	0.584
Urea	2.47	3.20	2.60	3.66	0.32	0.347	0.197	0.956
Ammonia	2.45	2.08	2.18	1.97	0.15	0.200	0.076	0.602
∑EAA	39.37^b	38.74^b	66.66^a	64.60^a	1.49	< 0.001	< 0.001	0.549
∑NEAA	121.50^b	119.18^b	156.95^a	146.85^a	3.61	< 0.001	< 0.001	0.230
TAA	160.87^b	157.92^b	223.61^a	211.45^a	3.93	< 0.001	< 0.001	0.256

SEM standard error of the mean, EAA essential amino acids, NEAA nonessential amino acids, TAA total amino acids
Dietary treatments were: basal diet + 0, 500, 1000, and 1500 mg/kg GAA, respectively. n = 6
^{a, b}Mean within rows with different letters differ significantly (P < 0.05)
Bold indicates P < 0.05

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ISSN: 2055-5660

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