Fig. 4

Suppurative meningoencephalitis in pigs. a Moderate, diffuse deposition of white material on the surface of the leptomeninges (arrow), accompanied by engorgement of leptomeningeal vessels and moderate hyperemia of the telencephalic cortex. b Telencephalic cortex with markedly thickened leptomeninges, with intense infiltrate comprised predominantly by neutrophils, fibrin deposition and marked diffuse congestion (asterisk). HE. × 40. c Cut surface of the brain, with intense dilation of lateral ventricles, third ventricle and midbrain aqueduct (hydrocephalus). On the ependymal surface, there is deposition of an opaque and irregular whitish material. d. Ventricle, ependyma and choroid plexus obscured and effaced by marked neutrophilic inflammatory infiltrate and fibrin deposition (suppurative ependymitis and plexochoroiditis) (asterisk). HE. × 100